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Phase 2 studies of ACC-001 in mild-to-moder-ate AD and in early AD are in progress (NCT00479557,NCT01284387, NCT01227564). This finding con-firmed the intuitive notion that adequate assessment of cerebrovascular reactivity in generaldepends on the occurrence and power of slow wave oscillations. Section 7.3 summarizescommon methods that are used to assess renal function and tox-icity in clinical settings and in the whole animal.

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